Access to this article can also be purchased.Varicella zoster virus (VZV) is an exclusively human neurotropic herpesvirus that causes varicella (chickenpox) during primary infection, after which the virus becomes latent in cranial nerve, dorsal root, and autonomic ganglia along the entire neuraxis.Zoster sine herpete (ZSH) refers to a condition in which dermatomal distribution pain occurs in the absence of an antecedent rash.We have changed the login procedure to improve access between AAN.com and the Neurology journals. The diagnosis of HZ is usually based on clinical presentation of prodrome and rash. You will be redirected to a login page where you can log in with your AAN ID number and password. If you have a subscription you may use the login form below to view the article. Des Weiteren ist es in manchen Fällen notwendig, eine Zellkultur anzulegen, um die Viren im Labor zu vermehren und damit nachweisen zu können. ScienceDirect ® is a registered trademark of Elsevier B.V.URL: https://www.sciencedirect.com/science/article/pii/B978012384913700023XURL: https://www.sciencedirect.com/science/article/pii/B9780444534880000122URL: https://www.sciencedirect.com/science/article/pii/B978072169491750096XURL: https://www.sciencedirect.com/science/article/pii/B9781416036180100414URL: https://www.sciencedirect.com/science/article/pii/B9780128136812000044URL: https://www.sciencedirect.com/science/article/pii/B9780323485661000127URL: https://www.sciencedirect.com/science/article/pii/B9781416048367000365URL: https://www.sciencedirect.com/science/article/pii/B9780323340441000195URL: https://www.sciencedirect.com/science/article/pii/B978044453480400014XProlonged radicular pain without rash may indicate Pain is the most common symptom of zoster and may precede the eruption by days to weeks. Polymerase chain reaction (PCR) is the most useful test for confirming cases of suspected zoster sine herpete (herpes zoster-type pain that occurs without a rash). 'Royal Free Hospital'.This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.Zoster sine herpete: Virologic verification by detection of anti-VZV IgG antibody in CSF HZ may present without rash, however, and particularly in the elderly (“In patients who do present with the characteristic zoster rash, the differential diagnosis is primarily between HZ and zosteriform herpes simplex.

This article requires a subscription to view the full text. Both immunofluorescence VZV antigen detection and VZV detection by viral polymerase chain reaction (PCR) are excellent tests with high specificity and sensitivity (90%–100%). Der Herpes zoster, deutsch Gürtelrose, ist die Zweitmanifestation einer Infektion mit Varizella-Zoster-Viren (VZV), die nach erfolgter Erstinfektion in den Neuronen und Gliazellen der Spinalganglien lebenslang persistieren.. ICD10-Code: B02.-. When a latent VZV virus reactivates, it causes clinical herpes zoster symptoms. Some cases of VZV reactivation result in a condition known as zoster sine herpete.

HZ patients are typically older, whereas herpes simplex patients often experience recurrent episodes and usually do not experience chronic pain.Although a clinical diagnosis is often sufficient in those patients presenting with the classic HZ rash, for cases involving atypical presentations and possible herpes simplex infection, laboratory testing can be useful. The notion of zoster sine herpete was initially provided by a report of multiple patients with dermatomal distribution radicular pain in areas distinct from pain with rash in zoster (Lewis, 1958).Currently, most clinicians regard zoster sine herpete exclusively as the occurrence of chronic radicular pain without rash. Nach ein… There are challenges to interpreting the results.Diagnosis of HZ and PHN relies upon a sound history and physical examination, often combined with laboratory diagnostic testing.

Um bei Zoster sine herpete eine sichere Diagnose stellen zu können, muss ein direkter Erregernachweis (Antigennachweis) mit speziellen Methoden erbracht werden.

A patient may have prodromal symptoms without developing the characteristic rash (Headache, Facial Pain, and Disorders of Facial SensationLiu, Volpe, and Galetta's Neuro-Ophthalmology (Third Edition)The diagnosis is usually straightforward when typical skin lesions are present, but can be elusive if absent (ScienceDirect ® is a registered trademark of Elsevier B.V.